This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1tx4
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1tx4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tx4, resolution 1.65Å" /> '''RHO/RHOGAP/GDP(DOT)...)
Next diff →
Revision as of 19:07, 29 October 2007
|
RHO/RHOGAP/GDP(DOT)ALF4 COMPLEX
Overview
Small G proteins of the Rho family, which includes Rho, Rac and Cdc42Hs, regulate phosphorylation pathways that control a range of biological, functions including cytoskeleton formation and cell proliferation. They, operate as molecular switches, cycling between the biologically active, GTP-bound form and the inactive GDP-bound state. Their rate of hydrolysis, of GTP to GDP by virtue of their intrinsic GTPase activity is slow, but, can be accelerated by up to 10(5)-fold through interaction with rhoGAP, a, GTPase-activating protein that stimulates Rho-family proteins. As such, rhoGAP plays a crucial role in regulating Rho-mediated signalling, pathways. Here we report the crystal structure of RhoA and rhoGAP, complexed with the transition-state analogue GDP.AlF4- at 1.65 A, resolution. ... [(full description)]
About this Structure
1TX4 is a [Protein complex] structure of sequences from [Homo sapiens] with MG, ALF and GDP as [ligands]. Full crystallographic information is available from [OCA].
Reference
Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue., Rittinger K, Walker PA, Eccleston JF, Smerdon SJ, Gamblin SJ, Nature. 1997 Oct 16;389(6652):758-62. PMID:9338791
Page seeded by OCA on Mon Oct 29 21:12:12 2007
