1glo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search

OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1glo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1glo, resolution 2.20&Aring;" /> '''CRYSTAL STRUCTURE O...)
Next diff →

Revision as of 19:08, 29 October 2007

Image:1glo.gif

1glo, resolution 2.20Å

Drag the structure with the mouse to rotate

CRYSTAL STRUCTURE OF CYS25SER MUTANT OF HUMAN CATHEPSIN S

Overview

Cathepsin S (EC 3.4.22.27), a cysteine proteinase of the papain, superfamily, plays a critical role in the generation of a major, histocompatibility complex (MHC) class II restricted T-cell response by, antigen-presenting cells. Therefore, selective inhibition of this enzyme, may be useful in modulating class II restricted T-cell responses in, immune-related disorders such as rheumatoid arthritis, multiple sclerosis, and extrinsic asthma. The three-dimensional structure at 2.2 A resolution, of the active-site Cys25-->Ser mutant presented here in an unliganded, state provides further insight useful for the design of selective enzyme, inhibitors.

About this Structure

1GLO is a [Single protein] structure of sequence from [Homo sapiens]. Active as [[1]], with EC number [3.4.22.27]. Full crystallographic information is available from [OCA].

Reference

Structure of a Cys25-->Ser mutant of human cathepsin S., Turkenburg JP, Lamers MB, Brzozowski AM, Wright LM, Hubbard RE, Sturt SL, Williams DH, Acta Crystallogr D Biol Crystallogr. 2002 Mar;58(Pt 3):451-5. Epub 2002, Feb 21. PMID:11856830

Page seeded by OCA on Mon Oct 29 21:12:51 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1glo"
Personal tools