Transcription Termination Factor Rho
From Proteopedia
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| - | + | <applet load='Rho1.pdb' size='350' frame='true' align='right' scene='Transcription_Termination_Factor_Rho/Rho1_pdb_hexamer_overview/1' /> | |
'''Transcription termination factor Rho''' is a ring-shaped RNA-DNA '''helicase''' that induces release of transcription complexes at specific loci of bacterial genomes. Several structures of Rho in various liganded states haven been solved by X-ray crystallography by the J. M. Berger lab (Berkeley): [[1a8v]], [[1pv4]], [[1pvo]], [[1xpr]], [[1xpu]], [[2a8v]], and [[2ht1]]. | '''Transcription termination factor Rho''' is a ring-shaped RNA-DNA '''helicase''' that induces release of transcription complexes at specific loci of bacterial genomes. Several structures of Rho in various liganded states haven been solved by X-ray crystallography by the J. M. Berger lab (Berkeley): [[1a8v]], [[1pv4]], [[1pvo]], [[1xpr]], [[1xpu]], [[2a8v]], and [[2ht1]]. | ||
| - | The [[Asymmetric Unit|asymmetric unit]] solved as [[2ht1]] contains only two chains, so it represents only one third of the [[Biological unit]], which is a homo-hexamer. | + | The [[Asymmetric Unit|asymmetric unit]] solved as [[2ht1]] contains only two chains, so it represents only one third of the [[Biological Unit|biological unit]], which is a homo-hexamer. The scene here shows this <scene name='Transcription_Termination_Factor_Rho/Rho1_pdb_hexamer_overview/1'>homo-hexamer in a closed state</scene> (file [[Image:Rho1.pdb]] derived from [2ht1]] by symmetry operations). |
| - | Here is one representation showing the <scene name='Transcription_Termination_Factor_Rho/Rho_closed_1/3'> | + | Here is one representation showing the same Rho hexamer in a closed state and with <scene name='Transcription_Termination_Factor_Rho/Rho_closed_1/3'>RNA fragments occupying both its primary and secondary binding sites</scene>. |
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Revision as of 20:46, 21 November 2008
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Transcription termination factor Rho is a ring-shaped RNA-DNA helicase that induces release of transcription complexes at specific loci of bacterial genomes. Several structures of Rho in various liganded states haven been solved by X-ray crystallography by the J. M. Berger lab (Berkeley): 1a8v, 1pv4, 1pvo, 1xpr, 1xpu, 2a8v, and 2ht1.
The asymmetric unit solved as 2ht1 contains only two chains, so it represents only one third of the biological unit, which is a homo-hexamer. The scene here shows this (file Image:Rho1.pdb derived from [2ht1]] by symmetry operations).
Here is one representation showing the same Rho hexamer in a closed state and with .
