1utr
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(New page: 200px<br /><applet load="1utr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1utr" /> '''UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)'''<br...)
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Revision as of 02:12, 21 November 2007
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UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)
Overview
Metabolites of polychlorinated biphenyls (PCBs) bind with high affinity to, uteroglobin, a small homodimeric protein that also binds progesterone. We, present the solution structure of the reduced form of rat uteroglobin in, complex with a PCB methylsulphone, (MeSO2)2-TCB. The structure reveals the, molecular basis for the accumulation of (MeSO2)2-TCB by uteroglobin. The, structure also shows how ligand binding and release might be controlled by, reduction/oxidation of two intermolecular disulphide bonds. Breakage of, these bonds induces a local unfolding of the N- and C-termini and a, separation of helices creating a channel into the binding site. These, effects make the ligand binding cavity readily accessible to entry of the, ligand.
About this Structure
1UTR is a Single protein structure of sequence from Rattus norvegicus with PCB as ligand. Full crystallographic information is available from OCA.
Reference
Solution structure of a mammalian PCB-binding protein in complex with a PCB., Hard T, Barnes HJ, Larsson C, Gustafsson JA, Lund J, Nat Struct Biol. 1995 Nov;2(11):983-9. PMID:7583672
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