Sandbox1
From Proteopedia
| Line 1: | Line 1: | ||
| - | + | Human Glutamine Synthetase Tertiary Structure: Pfam domains | |
| + | |||
| + | -(describe structure of protein leading in to a single chain) | ||
| + | -each chain contains 2 domains, the Glutamine synthetase beta grasp domain(N-terminus), and the glutamine synthetase catalytic domain (the C-terminus). In order to stabilize the molecule, the two domains are involved in the Van der Walls , Hydrogen . The Beta Grasp domain interact with the C-terminus of the next subunit. | ||
| + | -the two domains are proceeded by a meander of 3-24 residues that link the chains in the proteins core. | ||
| + | |||
| + | Beta Grasp domain (N-terminus) | ||
| + | -comprised of residues 43-123 | ||
| + | -binds glutamate, ammonia, and ATP | ||
| + | <show protein alignment image> | ||
| + | <show structure of the domain in viewer> | ||
| + | |||
| + | Catalytic domain (C-terminus) | ||
| + | -comprised of residues 129-382 | ||
| + | -how it functions is not described, more research is necessary here | ||
| + | |||
| + | <show alignment image> | ||
| + | <show structure of the domain in viewer> | ||
| + | |||
| + | Active site | ||
| + | -there are 10 active sites in the decamer of the protein, each formed from the beta grasp domain of one chain and the catalytic domain of the neighboring chain. | ||
| + | <show relation between chains, domains, and active sites with viewer> | ||
| + | -describe visually the important aspects of the active site | ||
| + | <show active site and ligands relationship, may need multiple scenes> | ||
Revision as of 21:25, 5 December 2008
Human Glutamine Synthetase Tertiary Structure: Pfam domains
-(describe structure of protein leading in to a single chain) -each chain contains 2 domains, the Glutamine synthetase beta grasp domain(N-terminus), and the glutamine synthetase catalytic domain (the C-terminus). In order to stabilize the molecule, the two domains are involved in the Van der Walls , Hydrogen . The Beta Grasp domain interact with the C-terminus of the next subunit. -the two domains are proceeded by a meander of 3-24 residues that link the chains in the proteins core.
Beta Grasp domain (N-terminus) -comprised of residues 43-123 -binds glutamate, ammonia, and ATP <show protein alignment image> <show structure of the domain in viewer>
Catalytic domain (C-terminus) -comprised of residues 129-382 -how it functions is not described, more research is necessary here
<show alignment image> <show structure of the domain in viewer>
Active site -there are 10 active sites in the decamer of the protein, each formed from the beta grasp domain of one chain and the catalytic domain of the neighboring chain. <show relation between chains, domains, and active sites with viewer> -describe visually the important aspects of the active site <show active site and ligands relationship, may need multiple scenes>
