1ush
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(New page: 200px<br /> <applet load="1ush" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ush, resolution 1.73Å" /> '''5'-NUCLEOTIDASE FRO...)
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Revision as of 19:12, 29 October 2007
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5'-NUCLEOTIDASE FROM E. COLI
Overview
The crystal structure of 5'-nucleotidase (5'-NT) from E. coli, also known, as UDP-sugar hydrolase, has been determined at 1.7 A resolution. Two zinc, ions are present in the active site, which is located in a cleft between, two domains. The dimetal center and a catalytic Asp-His dyad are the main, players in the catalytic mechanism. Structure-based sequence comparisons, show that the structure also provides a model for animal 5'-NTs, which, together with other ectonucleotidases terminate the action of nucleotides, as extracellular signaling substances in the nervous system.
About this Structure
1USH is a [Single protein] structure of sequence from [Escherichia coli] with ZN, CO3 and SO4 as [ligands]. Active as [[1]], with EC number [3.1.3.5]. Full crystallographic information is available from [OCA].
Reference
X-ray structure of the Escherichia coli periplasmic 5'-nucleotidase containing a dimetal catalytic site., Knofel T, Strater N, Nat Struct Biol. 1999 May;6(5):448-53. PMID:10331872
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