1vex
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(New page: 200px<br /><applet load="1vex" size="450" color="white" frame="true" align="right" spinBox="true" caption="1vex" /> '''F-spondin TSR domain 4'''<br /> ==Overview=...)
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Revision as of 02:40, 21 November 2007
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F-spondin TSR domain 4
Overview
F-spondin is a protein mainly associated with neuronal development. It, attaches to the extracellular matrix and acts in the axon guidance of the, developing nervous system. F-spondin consists of eight domains, six of, which are TSR domains. The TSR domain family binds a wide range of, targets. Here we present the NMR solution structures of TSR1 and TSR4. TSR, domains have an unusual fold that is characterized by a long, nonglobular, shape, consisting of two beta-strands and one irregular extended strand., Three disulfide bridges and stack of alternating tryptophan and arginine, side-chains stabilize the structure. TSR1 and TSR4 structures are similar, to each other and to the previously determined TSR domain X-ray structures, from another protein, TSP, although TSR4 exhibits a mobile loop not seen, in other structures.
About this Structure
1VEX is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Solution structures of the first and fourth TSR domains of F-spondin., Paakkonen K, Tossavainen H, Permi P, Rakkolainen H, Rauvala H, Raulo E, Kilpelainen I, Guntert P, Proteins. 2006 Aug 15;64(3):665-72. PMID:16736493
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