We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
Sandbox2qc8
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | {{ | + | {{STRUCTURE_2gls | PDB=2gls | SCENE= }} |
| - | + | ||
| - | + | ||
=Glutamine Synthetase: Secondary structures= | =Glutamine Synthetase: Secondary structures= | ||
| Line 21: | Line 19: | ||
=References= | =References= | ||
<references/> | <references/> | ||
| + | [[Image:Example.jpg]] | ||
Revision as of 17:39, 17 December 2008
Glutamine Synthetase: Secondary structures
Glutamine synthetase is composed of 12 . Each subunit is composed of 15 and 12 , as well as a .
Each subunit has an exposed NH2 terminus and buried COOH terminus as part of a helical thong. [1]
The beta sheets are arranged into two separate partial beta barrels, one of which encompasses the ligand complex.
The active site within the secondary structure can be called a "bifunnel," providing access to ATP and glutamate at opposing ends.[2]
The ligands present are Cl, Mn, Adenosine Diphosphate, and L-Methionine-S-Sulfoximine Phosphate.
References
- ↑ Yamashita, M., et al.,Refined Atomic Model of Glutamine Synthetase at 3.5A Resolution, The Journal of Biological Chemistry, 1989, 17681-17690.
- ↑ Eisenberg, D., et al., Structure-function relationships of glutamine synthetases, Biochimica et Biophysica Acta 1477 (2000), 122-145.
