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(→Glutamine Synthetase: Secondary structures)
(→Glutamine Synthetase: Secondary structures)
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The active site within the secondary structure can be called a "bifunnel," providing access to ATP and glutamate at opposing ends.<ref>Eisenberg, D., et al., Structure-function relationships of glutamine synthetases, Biochimica et Biophysica Acta 1477 (2000), 122-145.</ref>
The active site within the secondary structure can be called a "bifunnel," providing access to ATP and glutamate at opposing ends.<ref>Eisenberg, D., et al., Structure-function relationships of glutamine synthetases, Biochimica et Biophysica Acta 1477 (2000), 122-145.</ref>
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The only ligand present is a pair of Mn ions (Manganese) that the active site of each subunit.
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The ligands present are Cl, Mn, Adenosine Diphosphate, and L-Methionine-S-Sulfoximine Phosphate.
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=References=
=References=
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[[Image:Example.jpg]]
[[Image:Example.jpg]]

Revision as of 04:46, 18 December 2008

PDB ID 2gls

Drag the structure with the mouse to rotate
2gls, resolution 3.50Å ()
Ligands:
Activity: Glutamate--ammonia ligase, with EC number 6.3.1.2
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Glutamine Synthetase: Secondary structures

Glutamine synthetase is composed of 12 . Each subunit is composed of 15 and 12 , as well as a .

Each subunit has an exposed NH2 terminus and buried COOH terminus as part of a helical thong. [1]


The beta sheets are arranged into two separate partial beta barrels, one of which encompasses the ligand complex.

The active site within the secondary structure can be called a "bifunnel," providing access to ATP and glutamate at opposing ends.[2]

The only ligand present is a pair of Mn ions (Manganese) that the active site of each subunit.

References

  1. ↑ Yamashita, M., et al.,Refined Atomic Model of Glutamine Synthetase at 3.5A Resolution, The Journal of Biological Chemistry, 1989, 17681-17690.
  2. ↑ Eisenberg, D., et al., Structure-function relationships of glutamine synthetases, Biochimica et Biophysica Acta 1477 (2000), 122-145.

Image:Example.jpg

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