We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1vlk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search

OCA (Talk | contribs)
(New page: 200px<br /><applet load="1vlk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1vlk, resolution 1.9&Aring;" /> '''STRUCTURE OF VIRAL IN...)
Next diff →

Revision as of 02:49, 21 November 2007

Image:1vlk.gif

1vlk, resolution 1.9Å

Drag the structure with the mouse to rotate

STRUCTURE OF VIRAL INTERLEUKIN-10

Overview

The crystal structure of Epstein-Barr virus protein BCRF1, an analog of, cellular interleukin-10 (IL-10), has been determined at the resolution of, 1.9 A and refined to an R-factor 0.191. The structure of this cytokine is, similar to that of human IL-10 (hIL-10), forming an intercalated dimer of, two 17 kDa polypeptides related by a crystallographic 2-fold symmetry, axis. BCRF1 exhibits novel conformations of the N-terminal coil and of the, loop between helices A and B compared to hIL-10. These regions are likely, to be involved in binding of one or more components of the IL-10 receptor, system, and thus the structural differences may account for the lower, binding affinity and limited spectrum of biological activities of viral, IL-10, compared to hIL-10.

About this Structure

1VLK is a Single protein structure of sequence from Human herpesvirus 4. Full crystallographic information is available from OCA.

Reference

Crystal structure of Epstein-Barr virus protein BCRF1, a homolog of cellular interleukin-10., Zdanov A, Schalk-Hihi C, Menon S, Moore KW, Wlodawer A, J Mol Biol. 1997 May 2;268(2):460-7. PMID:9159483

Page seeded by OCA on Wed Nov 21 04:56:20 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1vlk"
Personal tools