3bym

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[[Image:3bym.jpg|left|200px]]
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===X-ray co-crystal structure aminobenzimidazole triazine 1 bound to Lck===
===X-ray co-crystal structure aminobenzimidazole triazine 1 bound to Lck===
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The line below this paragraph, {{ABSTRACT_PUBMED_18278858}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18278858 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18278858}}
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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3BYM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYM OCA].
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3BYM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYM OCA].
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==Reference==
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Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity., Martin MW, Newcomb J, Nunes JJ, Boucher C, Chai L, Epstein LF, Faust T, Flores S, Gallant P, Gore A, Gu Y, Hsieh F, Huang X, Kim JL, Middleton S, Morgenstern K, Oliveira-dos-Santos A, Patel VF, Powers D, Rose P, Tudor Y, Turci SM, Welcher AA, Zack D, Zhao H, Zhu L, Zhu X, Ghiron C, Ermann M, Johnston D, Saluste CG, J Med Chem. 2008 Mar 27;51(6):1637-48. Epub 2008 Feb 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18278858 18278858]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Single protein]]
 
[[Category: Huang, X.]]
[[Category: Huang, X.]]
[[Category: Alternative splicing]]
[[Category: Alternative splicing]]
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[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 17 14:27:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 09:02:33 2008''

Revision as of 07:02, 31 December 2008

Image:3bym.png

Template:STRUCTURE 3bym

Contents

X-ray co-crystal structure aminobenzimidazole triazine 1 bound to Lck

Template:ABSTRACT PUBMED 18278858

Disease

Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]

About this Structure

3BYM is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity., Martin MW, Newcomb J, Nunes JJ, Boucher C, Chai L, Epstein LF, Faust T, Flores S, Gallant P, Gore A, Gu Y, Hsieh F, Huang X, Kim JL, Middleton S, Morgenstern K, Oliveira-dos-Santos A, Patel VF, Powers D, Rose P, Tudor Y, Turci SM, Welcher AA, Zack D, Zhao H, Zhu L, Zhu X, Ghiron C, Ermann M, Johnston D, Saluste CG, J Med Chem. 2008 Mar 27;51(6):1637-48. Epub 2008 Feb 16. PMID:18278858

Page seeded by OCA on Wed Dec 31 09:02:33 2008

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