1vqa
From Proteopedia
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(New page: 200px<br /><applet load="1vqa" size="450" color="white" frame="true" align="right" spinBox="true" caption="1vqa, resolution 1.8Å" /> '''GENE V PROTEIN MUTANT...)
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Revision as of 02:54, 21 November 2007
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GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ALA 35 AND ILE 47 REPLACED BY LEU 47 (V35A, I47L)
Overview
The problem of rationally engineering protein molecules can be simplified, where effects of mutations on protein function are additive. Crystal, structures of single and double mutants in the hydrophobic core of gene V, protein indicate that structural and functional effects of core mutations, are additive when the regions structurally influenced by the mutations do, not substantially overlap. These regions of influence can provide a simple, basis for identifying sets of mutations that will show additive effects.
About this Structure
1VQA is a Single protein structure of sequence from Bacteriophage f1. Full crystallographic information is available from OCA.
Reference
Potential use of additivity of mutational effects in simplifying protein engineering., Skinner MM, Terwilliger TC, Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10753-7. PMID:8855252
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