3byo

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3byo.jpg|left|200px]]
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The entry 3byo is ON HOLD until Paper Publication
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{{STRUCTURE_3byo| PDB=3byo | SCENE= }}
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Authors: Huang, X.
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===X-Ray co-crystal structure of 2-amino-6-phenylpyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one 25 bound to Lck===
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Description: X-Ray co-crystal structure of 2-amino-6-phenylpyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one 25 bound to Lck
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 13:03:18 2008''
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{{ABSTRACT_PUBMED_18278858}}
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==Disease==
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Known disease associated with this structure: SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]]
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==About this Structure==
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3BYO is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYO OCA].
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==Reference==
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Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity., Martin MW, Newcomb J, Nunes JJ, Boucher C, Chai L, Epstein LF, Faust T, Flores S, Gallant P, Gore A, Gu Y, Hsieh F, Huang X, Kim JL, Middleton S, Morgenstern K, Oliveira-dos-Santos A, Patel VF, Powers D, Rose P, Tudor Y, Turci SM, Welcher AA, Zack D, Zhao H, Zhu L, Zhu X, Ghiron C, Ermann M, Johnston D, Saluste CG, J Med Chem. 2008 Mar 27;51(6):1637-48. Epub 2008 Feb 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18278858 18278858]
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[[Category: Homo sapiens]]
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[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Huang, X.]]
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[[Category: Alternative splicing]]
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[[Category: Atp-binding]]
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[[Category: Chromosomal rearrangement]]
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[[Category: Cytoplasm]]
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[[Category: Disease mutation]]
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[[Category: Host-virus interaction]]
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[[Category: Kinase domain]]
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[[Category: Lck]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Myristate]]
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[[Category: Nucleotide-binding]]
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[[Category: Palmitate]]
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[[Category: Phosphoprotein]]
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[[Category: Proto-oncogene]]
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[[Category: Sh2 domain]]
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[[Category: Sh3 domain]]
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[[Category: Transferase]]
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[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 10:15:16 2008''

Revision as of 08:15, 31 December 2008

Image:3byo.jpg

Template:STRUCTURE 3byo

Contents

X-Ray co-crystal structure of 2-amino-6-phenylpyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one 25 bound to Lck

Template:ABSTRACT PUBMED 18278858

Disease

Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]

About this Structure

3BYO is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity., Martin MW, Newcomb J, Nunes JJ, Boucher C, Chai L, Epstein LF, Faust T, Flores S, Gallant P, Gore A, Gu Y, Hsieh F, Huang X, Kim JL, Middleton S, Morgenstern K, Oliveira-dos-Santos A, Patel VF, Powers D, Rose P, Tudor Y, Turci SM, Welcher AA, Zack D, Zhao H, Zhu L, Zhu X, Ghiron C, Ermann M, Johnston D, Saluste CG, J Med Chem. 2008 Mar 27;51(6):1637-48. Epub 2008 Feb 16. PMID:18278858

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