1vsa
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(New page: 200px<br /><applet load="1vsa" size="450" color="white" frame="true" align="right" spinBox="true" caption="1vsa, resolution 3.710Å" /> '''Crystal Structure o...)
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Revision as of 02:59, 21 November 2007
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Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements. This file, 1VSA, contains the 50S ribosome subunit. 30S ribosome subunit is in the file 2OW8
Overview
Our understanding of the mechanism of protein synthesis has undergone, rapid progress in recent years as a result of low-resolution X-ray and, cryo-EM structures of ribosome functional complexes and high-resolution, structures of ribosomal subunits and vacant ribosomes. Here, we present, the crystal structure of the Thermus thermophilus 70S ribosome containing, a model mRNA and two tRNAs at 3.7 A resolution. Many structural details of, the interactions between the ribosome, tRNA, and mRNA in the P and E sites, and the ways in which tRNA structure is distorted by its interactions with, the ribosome are seen. Differences between the conformations of vacant and, tRNA-bound 70S ribosomes suggest an induced fit of the ribosome structure, in response to tRNA binding, including significant changes in the, peptidyl-transferase catalytic site.
About this Structure
1VSA is a Protein complex structure of sequences from Thermus thermophilus. This structure superseeds the now removed PDB entry 1VS9. Full crystallographic information is available from OCA.
Reference
Crystal structure of a 70S ribosome-tRNA complex reveals functional interactions and rearrangements., Korostelev A, Trakhanov S, Laurberg M, Noller HF, Cell. 2006 Sep 22;126(6):1065-77. Epub 2006 Sep 7. PMID:16962654
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