3bym
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 3BYM is a | + | 3BYM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYM OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific protein-tyrosine kinase]] | [[Category: Non-specific protein-tyrosine kinase]] | ||
| - | [[Category: | + | [[Category: Single protein]] |
| + | [[Category: Pdbx_ordinal=, <PDBx:audit_author.]] | ||
[[Category: Alternative splicing]] | [[Category: Alternative splicing]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
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[[Category: Tyrosine-protein kinase]] | [[Category: Tyrosine-protein kinase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 20:09:16 2008'' |
Revision as of 14:47, 1 January 2009
Contents |
X-ray co-crystal structure aminobenzimidazole triazine 1 bound to Lck
Template:ABSTRACT PUBMED 18278858
Disease
Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]
About this Structure
3BYM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity., Martin MW, Newcomb J, Nunes JJ, Boucher C, Chai L, Epstein LF, Faust T, Flores S, Gallant P, Gore A, Gu Y, Hsieh F, Huang X, Kim JL, Middleton S, Morgenstern K, Oliveira-dos-Santos A, Patel VF, Powers D, Rose P, Tudor Y, Turci SM, Welcher AA, Zack D, Zhao H, Zhu L, Zhu X, Ghiron C, Ermann M, Johnston D, Saluste CG, J Med Chem. 2008 Mar 27;51(6):1637-48. Epub 2008 Feb 16. PMID:18278858[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
Page seeded by OCA on Wed Dec 31 20:09:16 2008
Categories: Homo sapiens | Non-specific protein-tyrosine kinase | Single protein | Alternative splicing | Atp-binding | Chromosomal rearrangement | Cytoplasm | Disease mutation | Host-virus interaction | Kinase domain | Lck | Lipoprotein | Membrane | Myristate | Nucleotide-binding | Palmitate | Phosphoprotein | Proto-oncogene | Sh2 domain | Sh3 domain | Transferase | Tyrosine-protein kinase
