2oc8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 20: Line 20:
==About this Structure==
==About this Structure==
-
2OC8 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OC8 OCA].
+
2OC8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OC8 OCA].
==Reference==
==Reference==
Line 35: Line 35:
Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity., Bogen SL, Ruan S, Liu R, Agrawal S, Pichardo J, Prongay A, Baroudy B, Saksena AK, Girijavallabhan V, Njoroge FG, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1621-7. Epub 2006 Jan 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16387495 16387495]
Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity., Bogen SL, Ruan S, Liu R, Agrawal S, Pichardo J, Prongay A, Baroudy B, Saksena AK, Girijavallabhan V, Njoroge FG, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1621-7. Epub 2006 Jan 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16387495 16387495]
[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
-
[[Category: Arasappan, A.]]
+
[[Category: Protein complex]]
-
[[Category: Bennett, F.]]
+
[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
-
[[Category: Beyer, B M.]]
+
-
[[Category: Bogen, S L.]]
+
-
[[Category: Chen, K.]]
+
-
[[Category: Fischmann, T.]]
+
-
[[Category: Girijavallabhan, V.]]
+
-
[[Category: Guo, Z.]]
+
-
[[Category: Hong, Z.]]
+
-
[[Category: Ingram, R.]]
+
-
[[Category: Jao, E.]]
+
-
[[Category: Liu, Y T.]]
+
-
[[Category: Lovey, R G.]]
+
-
[[Category: Madison, V.]]
+
-
[[Category: Malcolm, B.]]
+
-
[[Category: Myers, J.]]
+
-
[[Category: Njoroge, F G.]]
+
-
[[Category: Pichardo, J.]]
+
-
[[Category: Prongay, A J.]]
+
-
[[Category: Prosise, W W.]]
+
-
[[Category: Ramanathan, L.]]
+
-
[[Category: Saksena, A K.]]
+
-
[[Category: Senior, M.]]
+
-
[[Category: Strickland, C.]]
+
-
[[Category: Taremi, S S.]]
+
-
[[Category: Venkatraman, S.]]
+
-
[[Category: Weber, P C.]]
+
-
[[Category: Yang, R S.]]
+
-
[[Category: Yao, N.]]
+
-
[[Category: Yarosh-Tomaine, T.]]
+
-
[[Category: Zhang, R.]]
+
[[Category: Hcv]]
[[Category: Hcv]]
[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
Line 72: Line 43:
[[Category: Viral protein]]
[[Category: Viral protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 7 08:47:13 2009''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 7 20:18:36 2009''

Revision as of 17:49, 8 January 2009

Image:2oc8.png

Template:STRUCTURE 2oc8

Structure of Hepatitis C Viral NS3 protease domain complexed with NS4A peptide and ketoamide SCH503034

Template:ABSTRACT PUBMED 17444623

About this Structure

2OC8 is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl] - 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization., Prongay AJ, Guo Z, Yao N, Pichardo J, Fischmann T, Strickland C, Myers J Jr, Weber PC, Beyer BM, Ingram R, Hong Z, Prosise WW, Ramanathan L, Taremi SS, Yarosh-Tomaine T, Zhang R, Senior M, Yang RS, Malcolm B, Arasappan A, Bennett F, Bogen SL, Chen K, Jao E, Liu YT, Lovey RG, Saksena AK, Venkatraman S, Girijavallabhan V, Njoroge FG, Madison V, J Med Chem. 2007 May 17;50(10):2310-8. Epub 2007 Apr 20. PMID:17444623

Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide., Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET, Harbeson SL, Rice CM, Murcko MA, Caron PR, Thomson JA, Cell. 1996 Oct 18;87(2):343-55. PMID:8861917

Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P'2 moiety with improved potency., Arasappan A, Njoroge FG, Chan TY, Bennett F, Bogen SL, Chen K, Gu H, Hong L, Jao E, Liu YT, Lovey RG, Parekh T, Pike RE, Pinto P, Santhanam B, Venkatraman S, Vaccaro H, Wang H, Yang X, Zhu Z, Mckittrick B, Saksena AK, Girijavallabhan V, Pichardo J, Butkiewicz N, Ingram R, Malcolm B, Prongay A, Yao N, Marten B, Madison V, Kemp S, Levy O, Lim-Wilby M, Tamura S, Ganguly AK, Bioorg Med Chem Lett. 2005 Oct 1;15(19):4180-4. PMID:16087332

Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease., Chen KX, Njoroge FG, Prongay A, Pichardo J, Madison V, Girijavallabhan V, Bioorg Med Chem Lett. 2005 Oct 15;15(20):4475-8. PMID:16112859

Hepatitis C virus NS3-4A serine protease inhibitors: use of a P2-P1 cyclopropyl alanine combination for improved potency., Bogen S, Saksena AK, Arasappan A, Gu H, Njoroge FG, Girijavallabhan V, Pichardo J, Butkiewicz N, Prongay A, Madison V, Bioorg Med Chem Lett. 2005 Oct 15;15(20):4515-9. PMID:16112862

Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity., Bogen SL, Ruan S, Liu R, Agrawal S, Pichardo J, Prongay A, Baroudy B, Saksena AK, Girijavallabhan V, Njoroge FG, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1621-7. Epub 2006 Jan 4. PMID:16387495[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]

Page seeded by OCA on Wed Jan 7 20:18:36 2009

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2oc8"
Personal tools