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Lactose Permease
From Proteopedia
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process of cellular respiration.<ref name="Gita C. Gidwani">[http://www.faqs.org/nutrition/Kwa-Men/Lactose-Intolerance.html]<ref/> | process of cellular respiration.<ref name="Gita C. Gidwani">[http://www.faqs.org/nutrition/Kwa-Men/Lactose-Intolerance.html]<ref/> | ||
| + | ====Structure of Lactose Permease===={{STRUCTURE_1PV7 | PDB=1PV7 | SCENE='Lactose_Permease/Beginning/1'}} | ||
Lactose permease is a transmembrane protien consisting of N- and C- terminal domains, each with <Scene> six transmembrane helices, symmetrically positioned within the permease. Six side chains have been determined to be irreplaceable with respect to active transport of | Lactose permease is a transmembrane protien consisting of N- and C- terminal domains, each with <Scene> six transmembrane helices, symmetrically positioned within the permease. Six side chains have been determined to be irreplaceable with respect to active transport of | ||
lactose. Those which are crucial for substrate binding are <Scene> Glu126, <Scene> Arg144, | lactose. Those which are crucial for substrate binding are <Scene> Glu126, <Scene> Arg144, | ||
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====References==== | ====References==== | ||
| - | + | <references /> | |
Replace the PDB id after the STRUCTURE_ and after PDB= to load | Replace the PDB id after the STRUCTURE_ and after PDB= to load | ||
and display another structure. | and display another structure. | ||
| - | {{ | + | {{STRUCTURE_1PV7 | PDB=1PV7 | SCENE='Lactose_Permease/Beginning/1'}} |
Revision as of 14:19, 15 January 2009
Function of Lactose Permease
Lactose Permease is a transmembrane protein thatfacilitates the passage of lactose across the phospholipid bi-layer of the cell membrane. The transport mechanism used is an active co-transport that uses the inwardly directed H+ electrochemical gradient as its driving force. As a result, the lactose is accompanied from the periplasm to the cytoplasm of the cell by an H+ proton.[1]
Lactose is a disaccharide carbohydrate found primarily in mammalian milk. It is a
disaccharide composed of the monosaccharides glucose and galactose. When lactose is ingested,
it is brought into cells in the digestive system by the protein Lactose Permease. Here it is
broken down into its monosaccharide subunits by the enzyme lactase so it may be used in the
process of cellular respiration.[2]
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