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3d08
From Proteopedia
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| + | {{STRUCTURE_3d08| PDB=3d08 | SCENE= }} | ||
| - | + | ===Human p53 core domain with hot spot mutation R249S and second-site suppressor mutation H168R=== | |
| - | Description: p53 (4) | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | <!-- |
| + | The line below this paragraph, {{ABSTRACT_PUBMED_18996393}}, adds the Publication Abstract to the page | ||
| + | (as it appears on PubMed at http://www.pubmed.gov), where 18996393 is the PubMed ID number. | ||
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| + | {{ABSTRACT_PUBMED_18996393}} | ||
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| + | ==Disease== | ||
| + | Known disease associated with this structure: Adrenal cortical carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Breast cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Colorectal cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Hepatocellular carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Histiocytoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Li-Fraumeni syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Multiple malignancy syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Nasopharyngeal carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Osteosarcoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Pancreatic cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Thyroid carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]] | ||
| + | |||
| + | ==About this Structure== | ||
| + | 3D08 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D08 OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:18996393</ref><references group="xtra"/> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Frolow, F.]] | ||
| + | [[Category: Rozenberg, H.]] | ||
| + | [[Category: Shakked, Z.]] | ||
| + | [[Category: Shimon, L J.W.]] | ||
| + | [[Category: Suad, O.]] | ||
| + | [[Category: Acetylation]] | ||
| + | [[Category: Activator]] | ||
| + | [[Category: Alternative splicing]] | ||
| + | [[Category: Anti-oncogene]] | ||
| + | [[Category: Apoptosis]] | ||
| + | [[Category: Cell cycle]] | ||
| + | [[Category: Covalent protein-rna linkage]] | ||
| + | [[Category: Cytoplasm]] | ||
| + | [[Category: Disease mutation]] | ||
| + | [[Category: Dna-binding]] | ||
| + | [[Category: Endoplasmic reticulum]] | ||
| + | [[Category: Glycoprotein]] | ||
| + | [[Category: Host-virus interaction]] | ||
| + | [[Category: Li-fraumeni syndrome]] | ||
| + | [[Category: Loop-sheet-helix motif]] | ||
| + | [[Category: Metal-binding]] | ||
| + | [[Category: Methylation]] | ||
| + | [[Category: Mutant protein]] | ||
| + | [[Category: Nucleus]] | ||
| + | [[Category: P53]] | ||
| + | [[Category: Phosphoprotein]] | ||
| + | [[Category: Polymorphism]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Transcription regulation]] | ||
| + | [[Category: Ubl conjugation]] | ||
| + | [[Category: Zinc]] | ||
| + | |||
| + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 10:44:10 2009'' | ||
Revision as of 08:44, 21 January 2009
Contents |
Human p53 core domain with hot spot mutation R249S and second-site suppressor mutation H168R
Template:ABSTRACT PUBMED 18996393
Disease
Known disease associated with this structure: Adrenal cortical carcinoma OMIM:[191170], Breast cancer OMIM:[191170], Colorectal cancer OMIM:[191170], Hepatocellular carcinoma OMIM:[191170], Histiocytoma OMIM:[191170], Li-Fraumeni syndrome OMIM:[191170], Multiple malignancy syndrome OMIM:[191170], Nasopharyngeal carcinoma OMIM:[191170], Osteosarcoma OMIM:[191170], Pancreatic cancer OMIM:[191170], Thyroid carcinoma OMIM:[191170]
About this Structure
3D08 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Suad O, Rozenberg H, Brosh R, Diskin-Posner Y, Kessler N, Shimon LJ, Frolow F, Liran A, Rotter V, Shakked Z. Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations. J Mol Biol. 2009 Jan 9;385(1):249-65. Epub 2008 Oct 30. PMID:18996393 doi:10.1016/j.jmb.2008.10.063
Page seeded by OCA on Wed Jan 21 10:44:10 2009
Categories: Homo sapiens | Frolow, F. | Rozenberg, H. | Shakked, Z. | Shimon, L J.W. | Suad, O. | Acetylation | Activator | Alternative splicing | Anti-oncogene | Apoptosis | Cell cycle | Covalent protein-rna linkage | Cytoplasm | Disease mutation | Dna-binding | Endoplasmic reticulum | Glycoprotein | Host-virus interaction | Li-fraumeni syndrome | Loop-sheet-helix motif | Metal-binding | Methylation | Mutant protein | Nucleus | P53 | Phosphoprotein | Polymorphism | Transcription | Transcription regulation | Ubl conjugation | Zinc
