1wlh
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(New page: 200px<br /><applet load="1wlh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wlh, resolution 2.80Å" /> '''Molecular structure ...)
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Revision as of 03:23, 21 November 2007
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Molecular structure of the rod domain of Dictyostelium filamin
Overview
Dictyostelium discoideum filamin (ddFLN) is a two-chain F-actin, crosslinking protein with an N-terminal actin-binding domain and a rod, domain constructed from six tandem repeats of a 100 residue motif that has, an immunoglobulin (Ig) fold. We report the 2.8 A resolution crystal, structure of a homodimer of rod repeats 4, 5 and 6. The two chains are, arranged in an antiparallel fashion and form an elongated element, which, is shortened, however, compared to a fully extended, linear configuration, because the long axis of each Ig domain is arranged at an angle to the, long axis of the rod. Same arrangement of repeats should also be present, in the rod domain of human FLNa, much longer than Dictyostelium FLN, which, forms an extended structure able to crosslink F-actin chains over, distances of more than 1000 A.
About this Structure
1WLH is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.
Reference
Molecular structure of the rod domain of dictyostelium filamin., Popowicz GM, Muller R, Noegel AA, Schleicher M, Huber R, Holak TA, J Mol Biol. 2004 Oct 1;342(5):1637-46. PMID:15364587
Page seeded by OCA on Wed Nov 21 05:30:38 2007
