This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1wua

From Proteopedia

(Difference between revisions)
Jump to: navigation, search

OCA (Talk | contribs)
(New page: 200px<br /><applet load="1wua" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wua, resolution 1.45&Aring;" /> '''The structure of Apl...)
Next diff →

Revision as of 03:33, 21 November 2007

Image:1wua.gif

1wua, resolution 1.45Å

Drag the structure with the mouse to rotate

The structure of Aplyronine A-actin complex

Overview

Aplyronine A, isolated from the sea hare Aplysia kurodai, possesses an, exceedingly potent antitumor effect in vivo and it is one of the promising, candidates as an anticancer drug. This macrolide is known to depolymerize, F-actin and inhibit the polymerization of actin by forming a 1:1 complex, with monomeric actin. The first complex structure of actin-aplyronine A, was determined via a synchrotron X-ray analysis at a 1.45 A resolution. As, expected, aplyronine A binds to a hydrophobic cleft composed of subdomains, 1 and 3 of actin by intercalating its aliphatic tail part into the actin, molecule as do the other reported F-actin depolymerizing agents., Unexpectedly, this complex structure shows the specific structural, features around the trimethylserine moiety, revealed as an important, moiety of aplyronine A for cytotoxicity against HeLa cells. Combining this, result and our previous one, the moiety should strongly relate to the, specific biological activity of aplyronine A; i.e. a potent antitumor, effect.

About this Structure

1WUA is a Single protein structure of sequence from Oryctolagus cuniculus with CA, ATP and AP8 as ligands. Full crystallographic information is available from OCA.

Reference

Structure basis for antitumor effect of aplyronine a., Hirata K, Muraoka S, Suenaga K, Kuroda T, Kato K, Tanaka H, Yamamoto M, Takata M, Yamada K, Kigoshi H, J Mol Biol. 2006 Mar 3;356(4):945-54. Epub 2005 Dec 27. PMID:16406066

Page seeded by OCA on Wed Nov 21 05:40:40 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wua"
Personal tools