2w0j

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(New page: '''Unreleased structure''' The entry 2w0j is ON HOLD until Paper Publication Authors: Lountos, G.T., Tropea, J.E., Zhang, D., Jobson, A.G., Pommier, Y., Shoemaker, R.H., Waugh, D.S. De...)
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'''Unreleased structure'''
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{{Seed}}
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[[Image:2w0j.jpg|left|200px]]
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The entry 2w0j is ON HOLD until Paper Publication
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{{STRUCTURE_2w0j| PDB=2w0j | SCENE= }}
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Authors: Lountos, G.T., Tropea, J.E., Zhang, D., Jobson, A.G., Pommier, Y., Shoemaker, R.H., Waugh, D.S.
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===CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH NSC 109555, A SPECIFIC INHIBITOR===
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Description: Crystal structure of Chk2 in complex with NSC 109555, a specific inhibitor
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 27 10:53:18 2008''
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{{ABSTRACT_PUBMED_19177354}}
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==About this Structure==
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2W0J is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0J OCA].
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==Reference==
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<ref group="xtra">PMID:19177354</ref><ref group="xtra">PMID:17616632</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Jobson, A G.]]
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[[Category: Lountos, G T.]]
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[[Category: Pommier, Y.]]
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[[Category: Shoemaker, R H.]]
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[[Category: Tropea, J E.]]
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[[Category: Waugh, D S.]]
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[[Category: Zhang, D.]]
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[[Category: Chk2 inhibitor]]
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[[Category: Kinase]]
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[[Category: Li-fraumeni syndrome]]
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[[Category: Nucleotide-binding]]
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[[Category: Oncology]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Structure-assisted drug design]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 11 12:37:34 2009''

Revision as of 10:37, 11 February 2009

Image:2w0j.jpg

Template:STRUCTURE 2w0j

CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH NSC 109555, A SPECIFIC INHIBITOR

Template:ABSTRACT PUBMED 19177354

About this Structure

2W0J is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Lountos GT, Tropea JE, Zhang D, Jobson AG, Pommier Y, Shoemaker RH, Waugh DS. Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor. Protein Sci. 2009 Jan;18(1):92-100. PMID:19177354 doi:10.1002/pro.16
  • Jobson AG, Cardellina JH 2nd, Scudiero D, Kondapaka S, Zhang H, Kim H, Shoemaker R, Pommier Y. Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase. Mol Pharmacol. 2007 Oct;72(4):876-84. Epub 2007 Jul 6. PMID:17616632 doi:10.1124/mol.107.035832

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