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3f8g
From Proteopedia
(Difference between revisions)
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| + | {{STRUCTURE_3f8g| PDB=3f8g | SCENE= }} | ||
| - | + | ===The X-ray structure of a dimeric variant of human pancreatic ribonuclease with high cytotoxic and antitumor activities=== | |
| - | Description: The X-ray structure of a dimeric variant of human pancreatic ribonuclease with high cytotoxic and antitumor activities | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed | + | <!-- |
| + | The line below this paragraph, {{ABSTRACT_PUBMED_19177350}}, adds the Publication Abstract to the page | ||
| + | (as it appears on PubMed at http://www.pubmed.gov), where 19177350 is the PubMed ID number. | ||
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| + | {{ABSTRACT_PUBMED_19177350}} | ||
| + | |||
| + | ==About this Structure== | ||
| + | 3F8G is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F8G OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:19177350</ref><ref group="xtra">PMID:15192098</ref><ref group="xtra">PMID:18164315</ref><ref group="xtra">PMID:10393896</ref><ref group="xtra">PMID:11485573</ref><references group="xtra"/> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Pancreatic ribonuclease]] | ||
| + | [[Category: Avella, G.]] | ||
| + | [[Category: Mazzarella, L.]] | ||
| + | [[Category: Merlino, A.]] | ||
| + | [[Category: Sica, F.]] | ||
| + | [[Category: 3d domain swapping]] | ||
| + | [[Category: Antitumor agent]] | ||
| + | [[Category: Dimer]] | ||
| + | [[Category: Endonuclease]] | ||
| + | [[Category: Glycoprotein]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Nuclease]] | ||
| + | [[Category: Ribonuclease]] | ||
| + | [[Category: Secreted]] | ||
| + | [[Category: Unswapped dimer]] | ||
| + | |||
| + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 11 12:43:09 2009'' | ||
Revision as of 10:43, 11 February 2009
The X-ray structure of a dimeric variant of human pancreatic ribonuclease with high cytotoxic and antitumor activities
Template:ABSTRACT PUBMED 19177350
About this Structure
3F8G is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Merlino A, Avella G, Di Gaetano S, Arciello A, Piccoli R, Mazzarella L, Sica F. Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant. Protein Sci. 2009 Jan;18(1):50-7. PMID:19177350 doi:10.1002/pro.6
- Sica F, Di Fiore A, Merlino A, Mazzarella L. Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease: an enzyme tailored to evade ribonuclease protein inhibitor. J Biol Chem. 2004 Aug 27;279(35):36753-60. Epub 2004 Jun 9. PMID:15192098 doi:http://dx.doi.org/10.1074/jbc.M405655200
- Merlino A, Ercole C, Picone D, Pizzo E, Mazzarella L, Sica F. The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme. J Mol Biol. 2008 Feb 15;376(2):427-37. Epub 2007 Nov 12. PMID:18164315 doi:http://dx.doi.org/10.1016/j.jmb.2007.11.008
- Piccoli R, Di Gaetano S, De Lorenzo C, Grauso M, Monaco C, Spalletti-Cernia D, Laccetti P, Cinatl J, Matousek J, D'Alessio G. A dimeric mutant of human pancreatic ribonuclease with selective cytotoxicity toward malignant cells. Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7768-73. PMID:10393896
- Di Gaetano S, D'alessio G, Piccoli R. Second generation antitumour human RNase: significance of its structural and functional features for the mechanism of antitumour action. Biochem J. 2001 Aug 15;358(Pt 1):241-7. PMID:11485573
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