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-	'''Major Facilitators''' are membrane proteins that help with both influx and outflux of specific small molecules. They are neither passive channels, nor do they active pumping, like the ATPases. Like a rocker-switch, they tilt between the two states 'outside open' and 'inside open'. This tilting (or switching) is triggered when a molecule has docked inside, and it transports the molecule to the other side. There are major facilitator uniporters, symporters, and antiporters. Antiporters usually transport a second, different, molecule, when switching back in the opposite direction. In 2009, there is still no structure data that would clearly show the transport process in major facilitators.	+	*[[1b0j]] - S642 mutant of mAc (''Sus scrofa'') with isocitrate (substrate)
-		+	*[[1b0k]] - S642 mutant of mAc (''Sus scrofa'') with fluorocitrate (inhibitor)
-	== Classification ==	+	*[[1b0m]] - S642 mutant of mAc (''Sus scrofa'') with fluorocitrate (inhibitor)
-	TCDB, the most sophisticated classification of transport proteins to date, classifies the major facilitators as family 2.A.1 in the clan of '''secondary active [[porters]]'''.	+	*[[1c96]] - S642 mutant of mAc (''Sus scrofa'') with citrate
-		+	*[[1aco]] - mAc (''Bos taurus'') with ''trans''-aconitate (inhibitor)
-	== Available structures ==	+	*[[1ami]] - mAc (''Bos taurus'') with methylisocitrate
-	The family has about 10,000 sequenced members from all living organisms. There are, however, only a few protein structures resolved.	+	*[[1amj]] - mAc (''Bos taurus'') with sulfate
-	* from ''E. coli'' K12:	+	*[[2b3x]] - cAc (human) as aconitase with Fe4S4
-	** the [[glycerol-3-phosphate transporter]] ([[1pw4]])	+	*[[2b3y]] - cAc (human) as aconitase with Fe4S4 and citrate
-	** the [[multidrug resistance protein]] D ([[2gfp]])	+	*[[2ipy]] - cAc (human) as IRP1 with feritin RNA
-	** the [[Lactose Permease|lactose permease]] ([[1pv7]], [[2cfp]], [[2cfq]], [[2v8n]])	+	*[[7acn]] - mAc (''Sus scrofa'') with isocitrate
-		+
-	== Weblinks ==	+
-	*[http://www.tcdb.org/ The TCDB database]	+
-	*[http://www.tcdb.org/tcdb/subclass2.php?tc=2.A.1 TCDB: 2.A.1 The Major Facilitator Superfamily (MFS)]	+
-	*[http://www.tcdb.org/pdb_structure.php TCDB: Transport proteins with PDB structures]	+

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Revision as of 17:19, 15 February 2009

• 1b0j - S642 mutant of mAc (Sus scrofa) with isocitrate (substrate)
• 1b0k - S642 mutant of mAc (Sus scrofa) with fluorocitrate (inhibitor)
• 1b0m - S642 mutant of mAc (Sus scrofa) with fluorocitrate (inhibitor)
• 1c96 - S642 mutant of mAc (Sus scrofa) with citrate
• 1aco - mAc (Bos taurus) with trans-aconitate (inhibitor)
• 1ami - mAc (Bos taurus) with methylisocitrate
• 1amj - mAc (Bos taurus) with sulfate
• 2b3x - cAc (human) as aconitase with Fe4S4
• 2b3y - cAc (human) as aconitase with Fe4S4 and citrate
• 2ipy - cAc (human) as IRP1 with feritin RNA
• 7acn - mAc (Sus scrofa) with isocitrate