2hal

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==About this Structure==
==About this Structure==
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2HAL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAL OCA].
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2HAL is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAL OCA].
==Reference==
==Reference==
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An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors., Yin J, Cherney MM, Bergmann EM, Zhang J, Huitema C, Pettersson H, Eltis LD, Vederas JC, James MN, J Mol Biol. 2006 Aug 25;361(4):673-86. Epub 2006 Jul 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16860823 16860823]
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<ref group="xtra">PMID:16860823</ref><ref group="xtra">PMID:16288920</ref><ref group="xtra">PMID:10603326</ref><ref group="xtra">PMID:9032381</ref><references group="xtra"/>
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Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site., Yin J, Bergmann EM, Cherney MM, Lall MS, Jain RP, Vederas JC, James MN, J Mol Biol. 2005 Dec 9;354(4):854-71. Epub 2005 Oct 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16288920 16288920]
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Crystal structure of an inhibitor complex of the 3C proteinase from hepatitis A virus (HAV) and implications for the polyprotein processing in HAV., Bergmann EM, Cherney MM, Mckendrick J, Frormann S, Luo C, Malcolm BA, Vederas JC, James MN, Virology. 1999 Dec 5;265(1):153-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10603326 10603326]
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The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition., Bergmann EM, Mosimann SC, Chernaia MM, Malcolm BA, James MN, J Virol. 1997 Mar;71(3):2436-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9032381 9032381]
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[[Category: Hepatitis a virus]]
[[Category: Hepatitis a virus]]
[[Category: Picornain 3C]]
[[Category: Picornain 3C]]
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[[Category: Single protein]]
 
[[Category: Bergmann, E M.]]
[[Category: Bergmann, E M.]]
[[Category: Cherney, M M.]]
[[Category: Cherney, M M.]]
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[[Category: Picornain]]
[[Category: Picornain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:53:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:37:37 2009''

Revision as of 10:37, 16 February 2009

Image:2hal.png

Template:STRUCTURE 2hal

An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors

Template:ABSTRACT PUBMED 16860823

About this Structure

2HAL is a 2 chains structure of sequences from Hepatitis a virus. Full crystallographic information is available from OCA.

Reference

  • Yin J, Cherney MM, Bergmann EM, Zhang J, Huitema C, Pettersson H, Eltis LD, Vederas JC, James MN. An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors. J Mol Biol. 2006 Aug 25;361(4):673-86. Epub 2006 Jul 7. PMID:16860823 doi:10.1016/j.jmb.2006.06.047
  • Yin J, Bergmann EM, Cherney MM, Lall MS, Jain RP, Vederas JC, James MN. Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site. J Mol Biol. 2005 Dec 9;354(4):854-71. Epub 2005 Oct 14. PMID:16288920 doi:10.1016/j.jmb.2005.09.074
  • Bergmann EM, Cherney MM, Mckendrick J, Frormann S, Luo C, Malcolm BA, Vederas JC, James MN. Crystal structure of an inhibitor complex of the 3C proteinase from hepatitis A virus (HAV) and implications for the polyprotein processing in HAV. Virology. 1999 Dec 5;265(1):153-63. PMID:10603326 doi:10.1006/viro.1999.9968
  • Bergmann EM, Mosimann SC, Chernaia MM, Malcolm BA, James MN. The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition. J Virol. 1997 Mar;71(3):2436-48. PMID:9032381

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