1xt6

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(New page: 200px<br /><applet load="1xt6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xt6, resolution 1.80&Aring;" /> '''S35C Flavodoxin Muta...)
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Revision as of 04:12, 21 November 2007

Image:1xt6.gif

1xt6, resolution 1.80Å

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S35C Flavodoxin Mutant in the semiquinone state

Overview

The crystallographic structure of an engineered flavodoxin mutant from, Desulfovibrio vulgaris has been analysed. Site-directed mutagenesis was, used to substitute serine 35 with a cysteine to provide a possible, covalent linkage. The crystal structure of the semiquinone form of this, mutant is similar to the corresponding oxidation state of the wild-type, flavodoxin. Analysis of the structural changes reveals the interaction, between N(5)H of the flavin and the carbonyl O atom of Gly61 to be, critical for modulation of the electrochemical properties of the protein.

About this Structure

1XT6 is a Single protein structure of sequence from Desulfovibrio vulgaris with FMN as ligand. Full crystallographic information is available from OCA.

Reference

Structure of S35C flavodoxin mutant from Desulfovibrio vulgaris in the semiquinone state., Artali R, Marchini N, Meneghetti F, Cavazzini D, Cassetta A, Sassone C, Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):481-4. Epub 2005, Mar 24. PMID:15805604

Page seeded by OCA on Wed Nov 21 06:19:44 2007

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