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1xwv
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(New page: 200px<br /><applet load="1xwv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xwv, resolution 1.83Å" /> '''Structure of the hou...)
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Revision as of 04:16, 21 November 2007
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Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity
Overview
The X-ray structure of the group 2 major allergen from Dermatophagoides, farinae (Der f 2) was determined to 1.83 A resolution. The overall Der f 2, structure comprises a single domain of immunoglobulin fold with two, anti-parallel beta-sheets. A large hydrophobic cavity is formed in the, interior of Der f 2. Structural comparisons to distantly related proteins, suggest a role in lipid binding. Immunoglobulin E (IgE) cross-reactivity, between group 2 house dust mite major allergens can be explained by, conserved surface areas representing IgE binding epitopes.
About this Structure
1XWV is a Single protein structure of sequence from Dermatophagoides farinae with PE3 and XPE as ligands. Full crystallographic information is available from OCA.
Reference
Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity., Johannessen BR, Skov LK, Kastrup JS, Kristensen O, Bolwig C, Larsen JN, Spangfort M, Lund K, Gajhede M, FEBS Lett. 2005 Feb 14;579(5):1208-12. Epub 2005 Jan 21. PMID:15710415
Page seeded by OCA on Wed Nov 21 06:23:49 2007
