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1y2q

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(New page: 200px<br /><applet load="1y2q" size="450" color="white" frame="true" align="right" spinBox="true" caption="1y2q, resolution 1.95&Aring;" /> '''Crystal structure of...)
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Revision as of 04:24, 21 November 2007

Image:1y2q.gif

1y2q, resolution 1.95Å

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Crystal structure of the editing domain of threonyl-tRNA synthetase from Pyrococcus abyssi

Overview

We report the crystal structure of an archaea-specific editing domain of, threonyl-tRNA synthetase that reveals a marked structural similarity to, D-amino acid deacylases found in eubacteria and eukaryotes. The domain can, bind D-amino acids despite a low sequence identity to other D-amino acid, deacylases. These results together indicate the presence of these, deacylases in all three kingdoms of life. This underlines an important, role they may have played in enforcing homochirality during translation.

About this Structure

1Y2Q is a Single protein structure of sequence from Pyrococcus abyssi. Active as Threonine--tRNA ligase, with EC number 6.1.1.3 Full crystallographic information is available from OCA.

Reference

A D-amino acid editing module coupled to the translational apparatus in archaea., Dwivedi S, Kruparani SP, Sankaranarayanan R, Nat Struct Mol Biol. 2005 Jun;12(6):556-7. Epub 2005 May 22. PMID:15908961

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