This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1ycj
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /><applet load="1ycj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ycj, resolution 1.95Å" /> '''Crystal structure of...)
Next diff →
Revision as of 04:33, 21 November 2007
|
Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate
Overview
The X-ray structure of the ligand-binding core of the kainate receptor, GluR5 (GluR5-S1S2) in complex with (S)-glutamate was determined to 1.95 A, resolution. The overall GluR5-S1S2 structure comprises two domains and is, similar to the related AMPA receptor GluR2-S1S2J. (S)-glutamate binds as, in GluR2-S1S2J. Distinct features are observed for Ser741, which, stabilizes a highly coordinated network of water molecules and forms an, interdomain bridge. The GluR5 complex exhibits a high degree of domain, closure (26 degrees) relative to apo GluR2-S1S2J. In addition, GluR5-S1S2, forms a novel dimer interface with a different arrangement of the two, protomers compared to GluR2-S1S2J.
About this Structure
1YCJ is a Single protein structure of sequence from Rattus norvegicus with SO4 and GLU as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate., Naur P, Vestergaard B, Skov LK, Egebjerg J, Gajhede M, Kastrup JS, FEBS Lett. 2005 Feb 14;579(5):1154-60. PMID:15710405
Page seeded by OCA on Wed Nov 21 06:41:04 2007
