2bku
From Proteopedia
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(New page: 200px<br /> <applet load="2bku" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bku, resolution 2.70Å" /> '''KAP95P:RANGTP COMPL...)
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Revision as of 19:28, 29 October 2007
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KAP95P:RANGTP COMPLEX
Overview
Nuclear protein import is mediated mainly by the transport factor, importin-beta that binds cytoplasmic cargo, most often via the, importin-alpha adaptor, and then transports it through nuclear pore, complexes. This active transport is driven by disassembly of the import, complex by nuclear RanGTP. The switch I and II loops of Ran change, conformation with nucleotide state, and regulate its interactions with, nuclear trafficking components. Importin-beta consists of 19 HEAT repeats, that are based on a pair of antiparallel alpha-helices (referred to as the, A- and B-helices). The HEAT repeats stack to yield two C-shaped arches, linked together to form a helicoidal molecule that has considerable, conformational flexibility. Here we present the structure of full-length, yeast importin-beta ... [(full description)]
About this Structure
2BKU is a [Protein complex] structure of sequences from [Canis familiaris] and [Saccharomyces cerevisiae] with MG and GTP as [ligands]. The following page contains interesting information on the relation of 2BKU with [Importins]. Full crystallographic information is available from [OCA].
Reference
Structural basis for nuclear import complex dissociation by RanGTP., Lee SJ, Matsuura Y, Liu SM, Stewart M, Nature. 2005 Jun 2;435(7042):693-6. Epub 2005 May 1. PMID:15864302
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