2bkt

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(New page: 200px<br /> <applet load="2bkt" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bkt, resolution 2.3&Aring;" /> '''CRYSTAL STRUCTURE OF...)
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Revision as of 19:29, 29 October 2007

Image:2bkt.gif

2bkt, resolution 2.3Å

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CRYSTAL STRUCTURE OF RENIN-PF00257567 COMPLEX

Overview

We have found that both enantiomeric configurations of the, 6-alkoxymethyl-1-aryl-2-piperazinone scaffold display equipotent renin, inhibition activity and similar SAR patterns. This enantiomeric, flexibility is in contrast to a previously reported, 3-alkoxymethyl-4-arylpiperidine scaffold.

About this Structure

2BKT is a [Single protein] structure of sequence from [Homo sapiens] with RPF as [ligand]. Active as [[1]], with EC number [3.4.23.15]. Full crystallographic information is available from [OCA].

Reference

Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors., Powell NA, Clay EH, Holsworth DD, Bryant JW, Ryan MJ, Jalaie M, Zhang E, Edmunds JJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2371-4. PMID:15837327

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