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1yv3

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(New page: 200px<br /><applet load="1yv3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yv3, resolution 2.0&Aring;" /> '''The structural basis ...)
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Revision as of 04:57, 21 November 2007

Image:1yv3.gif

1yv3, resolution 2.0Å

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The structural basis of blebbistatin inhibition and specificity for myosin II

Overview

Molecular motors play a central role in cytoskeletal-mediated cellular, processes and thus present an excellent target for cellular control by, pharmacological agents. Yet very few such compounds have been found. We, report here the structure of blebbistatin, which inhibits specific myosin, isoforms, bound to the motor domain of Dictyostelium discoideum myosin II., This reveals the structural basis for its specificity and provides insight, into the development of new agents.

About this Structure

1YV3 is a Single protein structure of sequence from Dictyostelium discoideum with MG, VO4, ADP, BIT and EDO as ligands. Full crystallographic information is available from OCA.

Reference

The structural basis of blebbistatin inhibition and specificity for myosin II., Allingham JS, Smith R, Rayment I, Nat Struct Mol Biol. 2005 Apr;12(4):378-9. Epub 2005 Mar 6. PMID:15750603

Page seeded by OCA on Wed Nov 21 07:04:24 2007

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