This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1yy3
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /><applet load="1yy3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yy3, resolution 2.88Å" /> '''Structure of S-Adeno...)
Next diff →
Revision as of 05:00, 21 November 2007
|
Structure of S-Adenosylmethionine:tRNA Ribosyltransferase-Isomerase (QueA)
Overview
The enzyme S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA), is involved in the biosynthesis of the hypermodified tRNA nucleoside, queuosine. It is unprecedented in nature as it uses the cofactor, S-adenosylmethionine as the donor of a ribosyl group. We have determined, the crystal structure of Bacillus subtilis QueA at a resolution of 2.9A., The structure reveals two domains representing a 6-stranded beta-barrel, and an alpha beta alpha-sandwich, respectively. All amino acid residues, invariant in the QueA enzymes of known sequence cluster at the interface, of the two domains indicating the localization of the substrate binding, region and active center. Comparison of the B. subtilis QueA structure, with the structure of QueA from Thermotoga maritima suggests a high domain, flexibility of this enzyme.
About this Structure
1YY3 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.
Reference
Crystal structure of Bacillus subtilis S-adenosylmethionine:tRNA ribosyltransferase-isomerase., Grimm C, Ficner R, Sgraja T, Haebel P, Klebe G, Reuter K, Biochem Biophys Res Commun. 2006 Dec 22;351(3):695-701. Epub 2006 Oct 30. PMID:17083917
Page seeded by OCA on Wed Nov 21 07:07:39 2007
