1zye
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(New page: 200px<br /><applet load="1zye" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zye, resolution 3.30Å" /> '''Crystal strucutre an...)
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Revision as of 05:36, 21 November 2007
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Crystal strucutre analysis of Bovine Mitochondrial Peroxiredoxin III
Overview
A crystal structure is reported for the C168S mutant of a typical 2-Cys, peroxiredoxin III (Prx III) from bovine mitochondria at a resolution of, 3.3 A. Prx III is present as a two-ring catenane comprising two, interlocking dodecameric toroids that are assembled from basic dimeric, units. Each ring has an external diameter of 150 A and encompasses a, central cavity that is 70 A in width. The concatenated dodecamers are, inclined at an angle of 55 degrees, which provides a large contact surface, between the rings. Dimer-dimer contacts involved in toroid formation are, hydrophobic in nature, whereas the 12 areas of contact between interlocked, rings arise from polar interactions. These two major modes of subunit, interaction provide important insights into possible mechanisms of, catenane formation.
About this Structure
1ZYE is a Single protein structure of sequence from Bos taurus. Active as Peroxiredoxin, with EC number 1.11.1.15 Full crystallographic information is available from OCA.
Reference
Bovine mitochondrial peroxiredoxin III forms a two-ring catenane., Cao Z, Roszak AW, Gourlay LJ, Lindsay JG, Isaacs NW, Structure. 2005 Nov;13(11):1661-4. PMID:16271889
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