1afq
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(New page: 200px<br /> <applet load="1afq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1afq, resolution 1.80Å" /> '''CRYSTAL STRUCTURE O...)
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Revision as of 19:36, 29 October 2007
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CRYSTAL STRUCTURE OF BOVINE GAMMA-CHYMOTRYPSIN COMPLEXED WITH A SYNTHETIC INHIBITOR
Overview
Crystals of gamma-chymotrypsin grown in aqueous solution were soaked in, n-hexane, and the structures of both the soaked and the native crystals, were determined to 2.2-A resolution. Seven hexane molecules and 130 water, molecules were found in the hexane-soaked crystals. Two of the seven, hexane molecules are found near the active site, and the rest are close to, hydrophobic regions on or near the surface of the enzyme. In the hexane, structure, water molecules that were not observed in the native structure, form a clathrate around one of the hexane molecules. Only 97 water, molecules were found in the native structure. The temperature factors for, atoms in the hexane environment are lower than those in the aqueous, environment. There are significant changes between the two structures ... [(full description)]
About this Structure
1AFQ is a [Single protein] structure of sequence from [Bos taurus] with SO4 as [ligand]. Active as [[1]], with EC number [3.4.21.1]. Full crystallographic information is available from [OCA].
Reference
X-ray crystal structure of gamma-chymotrypsin in hexane., Yennawar NH, Yennawar HP, Farber GK, Biochemistry. 1994 Jun 14;33(23):7326-36. PMID:8003497
Page seeded by OCA on Mon Oct 29 21:41:03 2007
