1z6j

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==About this Structure==
==About this Structure==
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1Z6J is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6J OCA].
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1Z6J is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6J OCA].
==Reference==
==Reference==
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Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa., Schweitzer BA, Neumann WL, Rahman HK, Kusturin CL, Sample KR, Poda GI, Kurumbail RG, Stevens AM, Stegeman RA, Stallings WC, South MS, Bioorg Med Chem Lett. 2005 Jun 15;15(12):3006-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15913999 15913999]
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<ref group="xtra">PMID:15913999</ref><ref group="xtra">PMID:12824026</ref><ref group="xtra">PMID:12954057</ref><references group="xtra"/>
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Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex., South MS, Case BL, Wood RS, Jones DE, Hayes MJ, Girard TJ, Lachance RM, Nicholson NS, Clare M, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, Parlow JJ, Bioorg Med Chem Lett. 2003 Jul 21;13(14):2319-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12824026 12824026]
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Polymer-assisted solution-phase library synthesis and crystal structure of alpha-ketothiazoles as tissue factor VIIa inhibitors., Parlow JJ, Dice TA, Lachance RM, Girard TJ, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, South MS, J Med Chem. 2003 Sep 11;46(19):4043-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12954057 12954057]
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[[Category: Coagulation factor VIIa]]
[[Category: Coagulation factor VIIa]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
 
[[Category: Kurumbail, R G.]]
[[Category: Kurumbail, R G.]]
[[Category: Kusturin, C L.]]
[[Category: Kusturin, C L.]]
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[[Category: Tissue factor]]
[[Category: Tissue factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:44:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 03:02:57 2009''

Revision as of 01:03, 17 February 2009

Image:1z6j.png

Template:STRUCTURE 1z6j

Contents

Crystal Structure of a ternary complex of Factor VIIa/Tissue Factor/Pyrazinone Inhibitor

Template:ABSTRACT PUBMED 15913999

Disease

Known disease associated with this structure: Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]

About this Structure

1Z6J is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Schweitzer BA, Neumann WL, Rahman HK, Kusturin CL, Sample KR, Poda GI, Kurumbail RG, Stevens AM, Stegeman RA, Stallings WC, South MS. Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3006-11. PMID:15913999 doi:10.1016/j.bmcl.2005.04.037
  • South MS, Case BL, Wood RS, Jones DE, Hayes MJ, Girard TJ, Lachance RM, Nicholson NS, Clare M, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, Parlow JJ. Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2319-25. PMID:12824026
  • Parlow JJ, Dice TA, Lachance RM, Girard TJ, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, South MS. Polymer-assisted solution-phase library synthesis and crystal structure of alpha-ketothiazoles as tissue factor VIIa inhibitors. J Med Chem. 2003 Sep 11;46(19):4043-9. PMID:12954057 doi:http://dx.doi.org/10.1021/jm030130t

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