2afj
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(New page: 200px<br /><applet load="2afj" size="450" color="white" frame="true" align="right" spinBox="true" caption="2afj" /> '''SPRY domain-containing SOCS box protein 2 (S...)
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Revision as of 05:58, 21 November 2007
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SPRY domain-containing SOCS box protein 2 (SSB-2)
Overview
The four mammalian SPRY domain-containing SOCS box proteins (SSB-1 to, SSB-4) are characterized by a C-terminal SOCS box and a central SPRY, domain. We have determined the first SPRY-domain structure, as part of, SSB-2, by NMR. This domain adopts a novel fold consisting of a, beta-sandwich structure formed by two four-stranded antiparallel, beta-sheets with a unique topology. We demonstrate that SSB-1, SSB-2 and, SSB-4, but not SSB-3, bind prostate apoptosis response protein-4 (Par-4)., Mutational analysis of SSB-2 loop regions identified conserved structural, determinants for its interaction with Par-4 and the hepatocyte growth, factor receptor, c-Met. Mutations in analogous loop regions of pyrin and, midline-1 SPRY domains have been shown to cause Mediterranean fever and, Opitz syndrome, respectively. Our findings provide a template for, SPRY-domain structure and an insight into the mechanism of SPRY-protein, interaction.
About this Structure
2AFJ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues., Masters SL, Yao S, Willson TA, Zhang JG, Palmer KR, Smith BJ, Babon JJ, Nicola NA, Norton RS, Nicholson SE, Nat Struct Mol Biol. 2006 Jan;13(1):77-84. Epub 2005 Dec 20. PMID:16369487
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