3caj

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==About this Structure==
==About this Structure==
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3CAJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CAJ OCA].
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3CAJ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CAJ OCA].
==Reference==
==Reference==
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Carbonic anhydrase inhibitors: The X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors., Di Fiore A, Pedone C, Antel J, Waldeck H, Witte A, Wurl M, Scozzafava A, Supuran CT, De Simone G, Bioorg Med Chem Lett. 2008 Mar 18;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18359629 18359629]
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<ref group="xtra">PMID:18359629</ref><ref group="xtra">PMID:8142888</ref><ref group="xtra">PMID:9541386</ref><references group="xtra"/>
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Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors., Smith GM, Alexander RS, Christianson DW, McKeever BM, Ponticello GS, Springer JP, Randall WC, Baldwin JJ, Habecker CN, Protein Sci. 1994 Jan;3(1):118-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8142888 8142888]
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Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination., Stams T, Chen Y, Boriack-Sjodin PA, Hurt JD, Liao J, May JA, Dean T, Laipis P, Silverman DN, Christianson DW, Protein Sci. 1998 Mar;7(3):556-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9541386 9541386]
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[[Category: Carbonate dehydratase]]
[[Category: Carbonate dehydratase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
 
[[Category: Fiore, A Di.]]
[[Category: Fiore, A Di.]]
[[Category: Simone, G De.]]
[[Category: Simone, G De.]]
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[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:53:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:27:14 2009''

Revision as of 02:27, 17 February 2009

Image:3caj.png

Template:STRUCTURE 3caj

Crystal structure of the human carbonic anhydrase II in complex with ethoxzolamide

Template:ABSTRACT PUBMED 18359629

About this Structure

3CAJ is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Di Fiore A, Pedone C, Antel J, Waldeck H, Witte A, Wurl M, Scozzafava A, Supuran CT, De Simone G. Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2669-74. Epub 2008 Mar 18. PMID:18359629 doi:10.1016/j.bmcl.2008.03.023
  • Smith GM, Alexander RS, Christianson DW, McKeever BM, Ponticello GS, Springer JP, Randall WC, Baldwin JJ, Habecker CN. Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors. Protein Sci. 1994 Jan;3(1):118-25. PMID:8142888
  • Stams T, Chen Y, Boriack-Sjodin PA, Hurt JD, Liao J, May JA, Dean T, Laipis P, Silverman DN, Christianson DW. Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination. Protein Sci. 1998 Mar;7(3):556-63. PMID:9541386 doi:10.1002/pro.5560070303

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