1vz8
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(New page: 200px<br /> <applet load="1vz8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1vz8, resolution 2.75Å" /> '''ORNITHINE ACETYLTRA...)
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Revision as of 19:40, 29 October 2007
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ORNITHINE ACETYLTRANSFERASE (ORF6 GENE PRODUCT- CLAVULANIC ACID BIOSYNTHESIS) FROM STREPTOMYCES CLAVULIGERUS (SEMET STRUCTURE)
Overview
The orf6 gene from the clavulanic acid biosynthesis gene cluster encodes, an OAT (ornithine acetyltransferase). Similar to other OATs the enzyme has, been shown to catalyse the reversible transfer of an acetyl group from, N-acetylornithine to glutamate. OATs are Ntn (N-terminal nucleophile), enzymes, but are distinct from the better-characterized Ntn hydrolase, enzymes as they catalyse acetyl transfer rather than a hydrolysis, reaction. In the present study, we describe the X-ray crystal structure of, the OAT, corresponding to the orf6 gene product, to 2.8 A (1 A=0.1 nm), resolution. The larger domain of the structure consists of an, alphabetabetaalpha sandwich as in the structures of Ntn hydrolase enzymes., However, differences in the connectivity reveal that OATs belong to a, structural ... [(full description)]
About this Structure
1VZ8 is a [Single protein] structure of sequence from [Streptomyces clavuligerus] with SO4 as [ligand]. Active as [[1]], with EC number [2.3.1.35]. Full crystallographic information is available from [OCA].
Reference
X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster., Elkins JM, Kershaw NJ, Schofield CJ, Biochem J. 2005 Jan 15;385(Pt 2):565-73. PMID:15352873
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