1gj4
From Proteopedia
(Difference between revisions)
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==About this Structure== | ==About this Structure== | ||
| - | 1GJ4 is a | + | 1GJ4 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GJ4 OCA]. |
==Reference== | ==Reference== | ||
| - | + | <ref group="xtra">PMID:11731301</ref><references group="xtra"/> | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
[[Category: Allen, D.]] | [[Category: Allen, D.]] | ||
| Line 49: | Line 48: | ||
[[Category: Zn+2-mediated inhibition]] | [[Category: Zn+2-mediated inhibition]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 07:16:48 2009'' |
Revision as of 05:16, 17 February 2009
SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA, SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN
Template:ABSTRACT PUBMED 11731301
About this Structure
1GJ4 is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Katz BA, Sprengeler PA, Luong C, Verner E, Elrod K, Kirtley M, Janc J, Spencer JR, Breitenbucher JG, Hui H, McGee D, Allen D, Martelli A, Mackman RL. Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets. Chem Biol. 2001 Nov;8(11):1107-21. PMID:11731301
Page seeded by OCA on Tue Feb 17 07:16:48 2009
Categories: Homo sapiens | Thrombin | Allen, D. | Breitenbucher, J G. | Hui, H. | Katz, B A. | Luong, C. | Mackman, R L. | Martelli, A. | McGee, D. | Spencer, J R. | Sprengeler, P A. | Verner, E. | Oxyanion hole water | Shift of pka of his57 | Specificity | Structure-based drug design | Three-centered | Trypsin | Urokinase | Very short hydrogen bond | Zn+2-mediated inhibition
