2b7m
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(New page: 200px<br /><applet load="2b7m" size="450" color="white" frame="true" align="right" spinBox="true" caption="2b7m, resolution 3.50Å" /> '''Crystal Structure of...)
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Revision as of 06:30, 21 November 2007
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Crystal Structure of the S. cerevisiae Exocyst Component Exo70p
Overview
The exocyst is an evolutionarily conserved multiprotein complex required, for the targeting and docking of post-Golgi vesicles to the plasma, membrane. Through its interactions with a variety of proteins, including, small GTPases, the exocyst is thought to integrate signals from the cell, and signal that vesicles arriving at the plasma membrane are ready for, fusion. Here we describe the three-dimensional crystal structure of one of, the components of the exocyst, Exo70p, from Saccharomyces cerevisiae at, 3.5A resolution. Exo70p binds the small GTPase Rho3p in a GTP-dependent, manner with an equilibrium dissociation constant of approximately 70, microM. Exo70p is an extended rod approximately 155 angstroms in length, composed principally of alpha helices, and is a novel fold. The structure, provides a first view of the Exo70 protein family and provides a framework, to study the molecular function of this exocyst component.
About this Structure
2B7M is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Crystal structure of the S.cerevisiae exocyst component Exo70p., Hamburger ZA, Hamburger AE, West AP Jr, Weis WI, J Mol Biol. 2006 Feb 10;356(1):9-21. Epub 2005 Nov 10. PMID:16359701
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