2c9n

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(New page: 200px<br /><applet load="2c9n" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c9n, resolution 3.3&Aring;" /> '''STRUCTURE OF THE EPST...)
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Revision as of 06:56, 21 November 2007


2c9n, resolution 3.3Å

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STRUCTURE OF THE EPSTEIN-BARR VIRUS ZEBRA PROTEIN AT APPROXIMATELY 3.5 ANGSTROM RESOLUTION

Overview

Epstein-Barr virus (EBV) causes infectious mononucleosis and is linked to, several human malignancies. EBV has a biphasic infection cycle consisting, of a latent and a lytic, replicative phase. The switch from latent to, lytic infection is triggered by the EBV immediate-early transcription, factor ZEBRA (BZLF1, Zta, Z, EB1). We present the crystal structure of, ZEBRA's DNA binding domain bound to an EBV lytic gene promoter element., ZEBRA exhibits a variant of the basic-region leucine zipper (bZIP) fold in, which a C-terminal moiety stabilizes the coiled coil involved in dimer, formation. The structure provides insights into ZEBRA's broad target site, specificity, preferential activation of specific EBV promoters in their, methylated state, ability to dimerize despite lacking a leucine zipper, motif, and failure to heterodimerize with cellular bZIP proteins. The, structure will allow for the design of new therapeutic agents that block, activation of the EBV lytic cycle.

About this Structure

2C9N is a Protein complex structure of sequences from Human herpesvirus 4. Full crystallographic information is available from OCA.

Reference

Structural basis of lytic cycle activation by the Epstein-Barr virus ZEBRA protein., Petosa C, Morand P, Baudin F, Moulin M, Artero JB, Muller CW, Mol Cell. 2006 Feb 17;21(4):565-72. PMID:16483937

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