2cna
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(New page: 200px<br /><applet load="2cna" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cna, resolution 2.0Å" /> '''THE COVALENT AND THRE...)
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Revision as of 07:03, 21 November 2007
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THE COVALENT AND THREE-DIMENSIONAL STRUCTURE OF CONCANAVALIN A, IV.ATOMIC COORDINATES,HYDROGEN BONDING,AND QUATERNARY STRUCTURE
Overview
The coordinates of the individual non-hydrogen atoms of the lectin, concanavalin A have been determined from the molecular model at 2.0-A, resolution and have been adjusted to make them consistent with the known, stereochemistry of the constituent amino acid residues. From the, coordinates, an analysis has been made of all intra- and intersubunit, interactions in the molecule, yielding a description of the, hydrogen-bonded structure of the monomer, including two extensive pleated, sheet structures and other features of the folding of the polypeptide, chain. The description of the noncovalent bonding is extended to include, the interactions involved in stabilization of the dimeric and tetrameric, structures of the molecule. The complete description of the molecular, structure provides a basis for analysis of the biological activities of, concanavalin A.
About this Structure
2CNA is a Single protein structure of sequence from Canavalia ensiformis with MN and CA as ligands. Full crystallographic information is available from OCA.
Reference
The covalent and three-dimensional structure of concanavalin A. IV. Atomic coordinates, hydrogen bonding, and quaternary structure., Reeke GN Jr, Becker JW, Edelman GM, J Biol Chem. 1975 Feb 25;250(4):1525-47. PMID:1112816
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