2phb
From Proteopedia
(Difference between revisions)
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==About this Structure== | ==About this Structure== | ||
| - | 2PHB is a | + | 2PHB is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PHB OCA]. |
==Reference== | ==Reference== | ||
| - | + | <ref group="xtra">PMID:17683371</ref><references group="xtra"/> | |
[[Category: Coagulation factor Xa]] | [[Category: Coagulation factor Xa]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Bigge, C F.]] | [[Category: Bigge, C F.]] | ||
[[Category: Finzel, B C.]] | [[Category: Finzel, B C.]] | ||
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[[Category: Fxa coagulation factor inhibitor]] | [[Category: Fxa coagulation factor inhibitor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:35:57 2009'' |
Revision as of 11:35, 17 February 2009
Contents |
An Orally Efficacious Factor Xa Inhibitor
Template:ABSTRACT PUBMED 17683371
Disease
Known disease associated with this structure: Factor X deficiency OMIM:[227600]
About this Structure
2PHB is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kohrt JT, Bigge CF, Bryant JW, Casimiro-Garcia A, Chi L, Cody WL, Dahring T, Dudley DA, Filipski KJ, Haarer S, Heemstra R, Janiczek N, Narasimhan L, McClanahan T, Peterson JT, Sahasrabudhe V, Schaum R, Van Huis CA, Welch KM, Zhang E, Leadley RJ, Edmunds JJ. The discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarb oxamide (PD 0348292), an orally efficacious factor Xa inhibitor. Chem Biol Drug Des. 2007 Aug;70(2):100-12. PMID:17683371 doi:10.1111/j.1747-0285.2007.00539.x
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