1thz

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==About this Structure==
==About this Structure==
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1THZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1THZ OCA].
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1THZ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1THZ OCA].
==Reference==
==Reference==
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Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening., Xu L, Li C, Olson AJ, Wilson IA, J Biol Chem. 2004 Nov 26;279(48):50555-65. Epub 2004 Sep 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15355974 15355974]
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<ref group="xtra">PMID:15355974</ref><ref group="xtra">PMID:12501179</ref><ref group="xtra">PMID:12974624</ref><ref group="xtra">PMID:14756553</ref><ref group="xtra">PMID:14966129</ref><references group="xtra"/>
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Structural insights into the avian AICAR transformylase mechanism., Wolan DW, Greasley SE, Beardsley GP, Wilson IA, Biochemistry. 2002 Dec 31;41(52):15505-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12501179 12501179]
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Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site., Wolan DW, Greasley SE, Wall MJ, Benkovic SJ, Wilson IA, Biochemistry. 2003 Sep 23;42(37):10904-14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12974624 12974624]
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Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor., Wolan DW, Cheong CG, Greasley SE, Wilson IA, Biochemistry. 2004 Feb 10;43(5):1171-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14756553 14756553]
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Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates., Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA, J Biol Chem. 2004 Apr 23;279(17):18034-45. Epub 2004 Feb 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14966129 14966129]
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Single protein]]
 
[[Category: Li, C.]]
[[Category: Li, C.]]
[[Category: Olson, A J.]]
[[Category: Olson, A J.]]
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[[Category: Virtual ligand screening]]
[[Category: Virtual ligand screening]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:57:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:42:40 2009''

Revision as of 11:42, 17 February 2009

Image:1thz.png

Template:STRUCTURE 1thz

Crystal Structure of Avian AICAR Transformylase in Complex with a Novel Inhibitor Identified by Virtual Ligand Screening

Template:ABSTRACT PUBMED 15355974

About this Structure

1THZ is a 2 chains structure of sequences from Gallus gallus. Full crystallographic information is available from OCA.

Reference

  • Xu L, Li C, Olson AJ, Wilson IA. Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening. J Biol Chem. 2004 Nov 26;279(48):50555-65. Epub 2004 Sep 7. PMID:15355974 doi:10.1074/jbc.M406801200
  • Wolan DW, Greasley SE, Beardsley GP, Wilson IA. Structural insights into the avian AICAR transformylase mechanism. Biochemistry. 2002 Dec 31;41(52):15505-13. PMID:12501179
  • Wolan DW, Greasley SE, Wall MJ, Benkovic SJ, Wilson IA. Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site. Biochemistry. 2003 Sep 23;42(37):10904-14. PMID:12974624 doi:http://dx.doi.org/10.1021/bi030106h
  • Wolan DW, Cheong CG, Greasley SE, Wilson IA. Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor. Biochemistry. 2004 Feb 10;43(5):1171-83. PMID:14756553 doi:10.1021/bi030162i
  • Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA. Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates. J Biol Chem. 2004 Apr 23;279(17):18034-45. Epub 2004 Feb 13. PMID:14966129 doi:10.1074/jbc.M313691200

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