2eb8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search

OCA (Talk | contribs)
(New page: 200px<br /><applet load="2eb8" size="450" color="white" frame="true" align="right" spinBox="true" caption="2eb8, resolution 1.65&Aring;" /> '''Crystal Structure of...)
Next diff →

Revision as of 07:53, 21 November 2007

Image:2eb8.jpg

2eb8, resolution 1.65Å

Drag the structure with the mouse to rotate

Crystal Structure of Cu(II)(Sal-Phe)/apo-Myoglobin

Overview

apo-Myoglobin (apo-Mb) was reconstituted with three copper complexes:, CuII(Sal-Phe) (1; Sal-Phe = N-salicylidene-l-phenylalanato), CuII(Sal-Leu), (2; Sal-Leu = N-salicylidene-l-leucinato), and CuII(Sal-Ala) (3; Sal-Ala =, N-salicylidene-l-alanato). The crystal structures of 1.apo-Mb (1.65 A, resolution) and 2.apo-Mb (1.8 A resolution) show that the coordination, geometry around the CuII atom in apo-Mb is distorted square-planar with, tridentate Sal-X and a Nepsilon atom of His64 in the apo-Mb cavity and the, plane of these copper complexes is perpendicular to that of heme. These, results suggest that the apo-Mb cavity can hold metal complexes with, various coordination geometries.

About this Structure

2EB8 is a Single protein structure of sequence from Physeter catodon with PO4 and CUP as ligands. Full crystallographic information is available from OCA.

Reference

Design and Structure Analysis of Artificial Metalloproteins: Selective Coordination of His64 to Copper Complexes with Square-Planar Structure in the apo-Myoglobin Scaffold., Abe S, Ueno T, Reddy PA, Okazaki S, Hikage T, Suzuki A, Yamane T, Nakajima H, Watanabe Y, Inorg Chem. 2007 Jun 25;46(13):5137-5139. Epub 2007 May 25. PMID:17523632

Page seeded by OCA on Wed Nov 21 10:00:20 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2eb8"
Personal tools