2f08
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(New page: 200px<br /><applet load="2f08" size="450" color="white" frame="true" align="right" spinBox="true" caption="2f08, resolution 2.20Å" /> '''Crystal structure of...)
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Revision as of 08:08, 21 November 2007
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Crystal structure of a major house dust mite allergen, Derf 2
Overview
Pyroglyphid house dust mites are a major source of allergens in house, dust. Mite allergens sensitize and induce asthma, rhinitis, and eczema in, a large portion of patients with allergic diseases. Here, the crystal, structure of a major mite allergen, Derf 2, derived from Dermatophagoides, farinae was solved by single isomorphous replacement method with anomalous, scattering (SIRAS) at 2.1A resolution. The present study also demonstrated, that the conformation of the allergen was critical in the determination of, Th1/Th2 shift based on physicochemical and immunological analyses. This, indicates that rigidly folded and singly dispersed structure is, essentially required for the generation of Th2 type cells by the allergen, while conformational variant protein leads to Th1 skewing, irrespective of, the same amino acid sequence. This structure/function relationship may, allow us to develop a novel strategy for hyposensitization therapy in, patients with allergic diseases triggered by house dust mite allergens.
About this Structure
2F08 is a Single protein structure of sequence from Dermatophagoides farinae with P4C as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure and some properties of a major house dust mite allergen, Derf 2., Suzuki M, Tanaka Y, Korematsu S, Mikami B, Minato N, Biochem Biophys Res Commun. 2006 Jan 13;339(2):679-86. Epub 2005 Nov 21. PMID:16313885
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