2f3n
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(New page: 200px<br /><applet load="2f3n" size="450" color="white" frame="true" align="right" spinBox="true" caption="2f3n, resolution 2.1Å" /> '''Crystal Structure of ...)
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Revision as of 08:13, 21 November 2007
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Crystal Structure of the native Shank SAM domain.
Overview
The postsynaptic density (PSD) is a complex assembly of proteins, associated with the postsynaptic membrane that organizes neurotransmitter, receptors, signaling pathways, and regulatory elements within a, cytoskeletal matrix. Here we show that the sterile alpha motif domain of, rat Shank3/ProSAP2, a master scaffolding protein located deep within the, PSD, can form large sheets composed of helical fibers stacked side by, side. Zn2+, which is found in high concentrations in the PSD, binds, tightly to Shank3 and may regulate assembly. Sheets of the Shank protein, could form a platform for the construction of the PSD complex.
About this Structure
2F3N is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
An architectural framework that may lie at the core of the postsynaptic density., Baron MK, Boeckers TM, Vaida B, Faham S, Gingery M, Sawaya MR, Salyer D, Gundelfinger ED, Bowie JU, Science. 2006 Jan 27;311(5760):531-5. PMID:16439662
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