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2f6m

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(New page: 200px<br /><applet load="2f6m" size="450" color="white" frame="true" align="right" spinBox="true" caption="2f6m, resolution 2.10&Aring;" /> '''Structure of a Vps23...)
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Revision as of 08:16, 21 November 2007

Image:2f6m.gif

2f6m, resolution 2.10Å

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Structure of a Vps23-C:Vps28-N subcomplex

Overview

The endosomal sorting complex required for transport (ESCRT) complexes are, central to receptor downregulation, lysosome biogenesis, and budding of, HIV. The yeast ESCRT-I complex contains the Vps23, Vps28, and Vps37, proteins, and its assembly is directed by the C-terminal steadiness box of, Vps23, the N-terminal half of Vps28, and the C-terminal half of Vps37. The, crystal structures of a Vps23:Vps28 core subcomplex and the, Vps23:Vps28:Vps37 core were solved at 2.1 and 2.8 A resolution. Each, subunit contains a structurally similar pair of helices that form the, core. The N-terminal domain of Vps28 has a hydrophobic binding site on its, surface that is conformationally dynamic. The C-terminal domain of Vps28, binds the ESCRT-II complex. The structure shows how ESCRT-I is assembled, by a compact core from which the Vps23 UEV domain, the Vps28 C domain, and, other domains project to bind their partners.

About this Structure

2F6M is a Protein complex structure of sequences from Saccharomyces cerevisiae with MG and DDQ as ligands. Full crystallographic information is available from OCA.

Reference

Structural and functional organization of the ESCRT-I trafficking complex., Kostelansky MS, Sun J, Lee S, Kim J, Ghirlando R, Hierro A, Emr SD, Hurley JH, Cell. 2006 Apr 7;125(1):113-26. PMID:16615894

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