2fkl

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==About this Structure==
==About this Structure==
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2FKL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FKL OCA].
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2FKL is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FKL OCA].
==Reference==
==Reference==
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Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions., Kong GK, Adams JJ, Harris HH, Boas JF, Curtain CC, Galatis D, Masters CL, Barnham KJ, McKinstry WJ, Cappai R, Parker MW, J Mol Biol. 2007 Mar 16;367(1):148-61. Epub 2006 Dec 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17239395 17239395]
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<ref group="xtra">PMID:17239395</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
 
[[Category: Kong, G K.W.]]
[[Category: Kong, G K.W.]]
[[Category: Parker, M W.]]
[[Category: Parker, M W.]]
[[Category: Alpha-beta two-layered sandwich]]
[[Category: Alpha-beta two-layered sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:33:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:34:43 2009''

Revision as of 16:34, 17 February 2009

Image:2fkl.png


PDB ID 2fkl

Drag the structure with the mouse to rotate
2fkl, resolution 2.50Å ()
Gene: APP (Homo sapiens)
Related: 1owt, 2fjz, 2fk1, 2fk2, 2fk3
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Contents

Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain (Residues 126- 189 of APP)

Template:ABSTRACT PUBMED 17239395

Disease

Known disease associated with this structure: Alzheimer disease-1, APP-related OMIM:[104760], Amyloidosis, cerebroarterial, Dutch type OMIM:[104760], Amyloidosis, cerebroarterial, Iowa type OMIM:[104760]

About this Structure

2FKL is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Kong GK, Adams JJ, Harris HH, Boas JF, Curtain CC, Galatis D, Masters CL, Barnham KJ, McKinstry WJ, Cappai R, Parker MW. Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions. J Mol Biol. 2007 Mar 16;367(1):148-61. Epub 2006 Dec 21. PMID:17239395 doi:10.1016/j.jmb.2006.12.041

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