This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2fe3
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /><applet load="2fe3" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fe3, resolution 1.75Å" /> '''The crystal structur...)
Next diff →
Revision as of 08:23, 21 November 2007
|
The crystal structure of bacillus subtilis PerR-Zn reveals a novel Zn(Cys)4 Structural redox switch
Overview
Bacteria adapt to elevated levels of Reactive Oxygen Species (ROS) by, increasing the expression of defence and repair proteins, which is, regulated by ROS responsive transcription factors. In Bacillus subtilis, the zinc protein PerR, a peroxide sensor that binds DNA in the presence of, a regulatory metal Mn2+ or Fe2+, mediates the adaptive response to H2O2., This study presents the first crystal structure of apo-PerR-Zn which shows, that all four cysteine residues of the protein are involved in zinc, co-ordination. The Zn(Cys)4 site locks the dimerization domain and, stabilizes the dimer. Sequence alignment of PerR-like proteins supports, that this structural site may constitute a distinctive feature of this, class of peroxide stress regulators.
About this Structure
2FE3 is a Single protein structure of sequence from Bacillus subtilis with ZN as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of the apo-PerR-Zn protein from Bacillus subtilis., Traore DA, El Ghazouani A, Ilango S, Dupuy J, Jacquamet L, Ferrer JL, Caux-Thang C, Duarte V, Latour JM, Mol Microbiol. 2006 Sep;61(5):1211-9. PMID:16925555
Page seeded by OCA on Wed Nov 21 10:30:26 2007
